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Call for Papers: The Evolving Biological Landscape of Upper GI Cancer – Implications for Precision Oncology

Introduction

Upper gastrointestinal (GI) cancers—which include oesophageal and gastric cancers—have seen major advances in their biological understanding and clinical treatment. The implementation of Precision Oncology in Upper Gastrointestinal Cancer establishes new standards for the classification, diagnosis and treatment of these diseases.

Upper GI cancers now receive their diagnostic assessment through molecular research on upper GI tumours and immune system evaluation, identifying treatable genetic biomarkers, whereas previously they relied on anatomical and histopathological characteristics. The development of molecular profiling methods for oesophageal cancer and the analysis of Genomic alterations in gastric cancer have created new treatment methods which permit doctors to customise patient care.

The special issue of ESMO Gastrointestinal Oncology aims to document and develop the current biological understanding of this area. We invite high-quality original research, comprehensive reviews, and forward-looking perspectives that integrate translational biology with clinical Immunotherapy in upper GI cancer.

Scope

This special issue seeks manuscripts that explore the biological complexity and clinical implications of Precision Oncology in Gastrointestinal Cancer. The invitation requests high-quality submissions that investigate molecular characteristics of upper gastrointestinal tumours and their newly identified disease subtypes and current developments in oesophageal cancer molecular profiling, which transform diagnostic and treatment methods.

The study should investigate how researchers discover and validate biomarkers that they use to diagnose upper gastrointestinal tumours. The research should focus on two main areas, which include gastric cancer genomic changes and their impact on clinical outcomes and the study of how tumours develop resistance and advance. The research study will accept immunotherapy progress studies that demonstrate their ability to enhance treatment results for upper gastrointestinal cancer patients.

The issue also supports research that combines translational biology with personalised treatment methods and biomarker-based decision processes, which are used throughout different disease stages. Interdisciplinary contributions that connect molecular biology with pathology and immunology and clinical oncology will help advance innovative precision oncology frameworks for upper gastrointestinal cancers.

Know More About This Issue

Genomic diversity and immune system interactions and adaptive resistance mechanisms together define the biological characteristics of upper gastrointestinal cancers. The most recent study on upper gastrointestinal cancer received funding from immunotherapy research and targeted treatment development to establish new clinical guidelines and expand treatment options.

Biological markers used in upper gastrointestinal cancer diagnosis conduct their primary function through their ability to enhance treatment choices and response prediction. The development of personalised oncology systems requires complete knowledge of gastric cancer genomic changes and advanced molecular analysis methods for oesophageal cancer.

This special issue aims to provide clinicians and researchers with a coherent and clinically actionable framework for integrating biological insights into everyday upper GI cancer care.

Oncology in Upper Gastrointestinal Cancer

Key Themes

Researchers are invited to submit manuscripts addressing, but not limited to, the following themes:

  • Precision Oncology applies to Upper Gastrointestinal Cancer research throughout all disease stages.
  • The study examines Molecular characterization of upper GI tumors through molecular analysis and subtype identification.
  • The research studies how immunotherapy affects upper gastrointestinal cancer treatment through its impact on immune microenvironments.
  • The study investigates the relationship between genomic changes in gastric cancer and their effects on treatment outcomes.
  • The study examines how oesophageal cancer functions through molecular profiling and resistance mechanism identification.
  • The research combines genomic data with molecular information and clinical research through its translational genomic work.
  • The research investigates upper gastrointestinal cancers through clinical implementation of their discovered Biomarkers in upper GI malignancies.
  • The study develops customised treatment pathways for patients with upper gastrointestinal cancers.

    • How We Support Your Submission

    The requirements for publishing in a high-impact oncology special issue demand that researchers demonstrate their ability to develop effective translational designs and biological expertise and provide clear clinical results. The PhD Assistance Research Lab provides complete manuscript writing help to researchers who work on Precision Oncology research in Upper Gastrointestinal Cancer.

  • Academic editing and manuscript refinement for clarity and coherence
  • Guidance on research design, conceptual framework and methodology alignment
  • Support in integrating paleobotanical, phylogenetic and ecological data effectively
  • Structural and language enhancement to meet international publication standards
  • Assistance with journal formatting, referencing and submission requirements
  • Support in addressing reviewer comments and revising manuscripts for final acceptance.
  • The expert team guarantees your manuscript will achieve the necessary scholarly standards for successful publication.

    • Journal Guidelines:

  • The manuscripts must show original research which has not been sent to any other publication for evaluation.
  • The final version needs all authors to provide their approval while they must disclose any possible conflict of interest.
  • The submission process requires strict compliance with the journal’s Guide for Authors which serves as the official document for submissions.
  • Authors need to submit their manuscripts through the Editorial Manager® system for evaluation.
  • The article type should be selected as “VSI: Biology of Upper GI Cancer and Precision Oncology.”
  • All submissions will undergo rigorous peer review by at least two independent experts.

    • Important Dates

    Submission Deadline: 20 June 2026

    To ensure successful and timely submission to the special issue “The Evolving Biological Landscape of Upper GI Cancer: Implications for Precision Oncology,” researchers are encouraged to seek expert publication support from conceptualisation to final submission.

    Free Guide: How to Write the Journal Manuscript

    Book a free consultation to get guidance from the PhD assistance research lab for writing a credible research manuscript and submitting it in the high-quality journal.

    Reference

    van Laarhoven, H. W. M. (2026, February 20). Call for papers: The evolving biological landscape of upper GI cancer: Implications for precision oncology (Special issue of ESMO Gastrointestinal Oncology). Elsevier.

     https://www.sciencedirect.com/special-issue/330712/the-evolving-biological-landscape-of-upper-gi-cancer-implications-for-precision-oncology

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